Yogesh C. Patel, MD, PhD, FACP, FRACP(c), FRSC, OC
Dr. Yogesh C. Patel, Professor of Medicine, Neurology and Neurosurgery, McGill University, has made outstanding original contributions to our understanding of the basic and applied functions of the peptide hormone somatostatin and is recognized as a foremost international authority on the peptide and its receptor family. He has published over 200 scientific articles and illuminated virtually every aspect of somatostatin function including its biosynthesis, posttranslational processing, gene regulation, metabolism, mechanism of action, and somatostatin dysfunction in diseases such as diabetes, cancer, and neurodegeneration. He developed one of the earliest radioimmunoassays for somatostatin and was the first to report that somatostatin was released from nerve endings and thus subserved a neurotransmitter function in the brain. Dr. Patel's group first described somatostatin receptors in brain, and showed that there were several different types that associate with other receptors to create novel receptor pairs known as heterodimers.
Dr. Patel's research has been extended into the clinical domain through the application of somatostatin receptor analysis in cancer and the use of somatostatin analogs for tumor diagnosis by somatostatin receptor imaging as well as for therapy. His publications have collectively received over 7100 citations.